Comprehensive Asian Genomic Database

Rainbow Asian Genomic Database, a clinically curated dataset integrating whole genome sequencing (WGS), whole exome sequencing (WES), pharmacogenomics, and polygenic risk data from over 3,000 deeply phenotyped individuals of Asian ancestry.

This initiative addresses a critical gap in global genomics: the underrepresentation of Asian populations in genomic databases, which has historically limited the accuracy and clinical utility of genetic testing for Asian patients.

A Genomics Resource for Precision Medicine

The Rainbow Asian Genomic Database combines:

  • Whole Genome and Whole Exome Sequencing data

  • Pharmacogenomic profiles covering drug metabolism and response

  • Polygenic risk scores (PRS) across cardiometabolic, oncologic, and neurodevelopmental conditions

  • Proteomic profiles of 7,000 proteins for 4 to 5 year risk prediction of cardiovascular disease, prostate cancer, lung cancer, and dementia

  • Deep phenotyping, with systematically recorded clinical features and symptoms

By integrating these layers, the database enables more accurate genotype - phenotype correlations, improved variant interpretation, and enhanced disease risk prediction in Asian populations.

Addressing the Asian Data Gap

“Most existing genomic reference datasets are heavily skewed toward European populations,” said Daniel Siu, CEO of Rainbow Genomics. “This creates real clinical limitations, as variants may be misclassified, and risk predictions may be less accurate for Asian individuals. Our goal is to build an Asian-relevant genomic foundation to support more precise, equitable healthcare.”

Clinical and Research Applications

The database is designed to support:

  • Neurodevelopmental and pediatric diagnosis of children with complex symptoms

  • Oncology and cardiometabolic risk assessment using ancestry-adjusted PRS combined with traditional gene testing approaches

  • Rare disease diagnosis through improved variant interpretation

  • Pharmacogenomic-guided prescribing

  • Clinical decision for physicians

Deep Phenotyping as a Differentiator

Unlike many genomic datasets, the Rainbow database emphasizes deep clinical phenotyping, with structured symptom and clinical data linked to genomic findings.

This enables:

  • Higher confidence in variant pathogenicity assessment

  • Enhanced identification of novel genotype - phenotype associations, helping to address ongoing challenges in the interpretation of variants in non-European populations.

  • More clinically actionable insights

Built for Asia, Connected Globally

The dataset focuses on Asian populations, including individuals from Hong Kong and the broader Asia-Pacific region, while being generated and curated under international clinical standards (CAP, CLIA, ACMG, AMP).

Future Expansion

Rainbow plans to expand the database to:

  • 10,000+ individuals over the next phase

  • Include multi-omics layers including proteomics using over 7000 proteins per patient